KMID : 0438420080150020091
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Korean Journal of Bone Metabolism 2008 Volume.15 No. 2 p.91 ~ p.98
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Diabetes and Osteoporosis
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Oh Ki-Won
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Abstract
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Longer life expectancy and increased obesity contribute to an increasing incidence of diabetes mellitus and osteoporosis.
Recent meta-analyses and cohort studies confirm that diabetes is associated with higher fracture risk. Patients with type
2 diabetes display an increased fracture risk despite a higher bone mass, which is mainly attributable to non-skeletal risk
factors. Patients with type 1 diabetes may have impaired bone formation because of the absence of the anabolic effects
of insulin and IGF-1 system. Several clinical studies have reported adverse skeletal actions of PPAR¥ã agonist in humans.
Obesity regulates bone metabolism not only by increasing weight loading but by modulating adipokines which are
known to affect bone remodeling.
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KEYWORD
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Osteoporosis, Diabetes, Obesity, Insulin, IGF-1, PPAR¥ã, Adipokine
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